Introduction Up to one third of colorectal cancers show familial clustering and 5% are
hereditary single-gene disorders. Hereditary non-polyposis colorectal cancer comprises …

Background The hereditary non-polyposis colorectal cancer (HNPCC) subset of tumours
can broadly be divided into tumours caused by an underlying mismatch-repair gene …

In the past two decades, significant advances have been made in our understanding of
colorectal (CRC) tumors with DNA mismatch (MMR) repair deficiency. The knowledge from …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide.
Hereditary CRC syndromes account for approximately 5–10% of all CRC, with a lifetime risk …

Approximately one‐third of individuals diagnosed with colorectal cancer have a family
history of cancer, suggesting that CRCs may result from a heritable component. Despite the …

Introduction Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary
nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial …

Hereditary nonpolyposis colorectal cancer (HNPCC) is common, accounting for about 4–6%
of the total colorectal cancer burden. It is heterogeneous and appears to be delineated into …

The genomic causes and clinical manifestations of hereditary colorectal cancer (HCRC)
might be stratified into 2 groups, namely, familial (FCRC) and a limited sense of HCRC …

Recent advances in hereditary nonpolyposis colorectal cancer (HNPCC) have been made
based on the discovery early in this decade that germline mutations in genes responsible for …

Hereditary nonpolyposis colorectal cancer (HNPCC), also termed Lynch syndrome, was
originally called cancer family syndrome. Historically, in 1913 Aldred Warthin, a pathologist …