Bone marrow transplantation (BMT) is a widely used therapy for blood cancers and primary
immunodeficiency. Following transplant, the thymus plays a key role in immune …

Acute graft-versus-host disease (aGVHD) impairs thymus-dependent T-cell regeneration in
recipients of allogeneic bone marrow transplants through yet to be defined mechanisms …

After hematopoietic stem cell transplantation, the persistence and expansion of grafted
mature postthymic T cells allow both transfer of donor immunologic memory and generation …

During acute graft-versus-host disease (aGVHD) in mice, autoreactive T cells can be
generated de novo in the host thymus implying an impairment in self-tolerance induction. As …

A favorable outcome of allogeneic hematopoietic stem-cell transplantation (HSCT) depends
on the complete reconstitution of the host's immune system. While recovery of peripheral T …

For several leukemia patients, allogeneic stem cell transplantation (allogeneic-SCT) is the
unique therapeutic modality that could potentially cure their disease. Despite significant …

Animal models with impaired thymic negative selection do not always cause autoimmune
diseases despite the development of an autoreactive T-cell repertoire. We investigated the …

Cytoreductive conditioning regimens used in the context of allogeneic hematopoietic cell
transplantation (HCT) elicit deficits in innate and adaptive immunity, which predispose …

The clinical success of allogeneic hematopoietic stem cell transplantation (HSCT) depends
on the appropriate reconstitution of the host's immune system. While recovery of T-cell …

Restoring T cell competence is a significant clinical challenge in patients whose thymic
function is severely compromised due to age or cytoreductive conditioning. Here, we …