T-cell Acute Lymphoblastic Leukaemia (T-ALL) results from the malignant transformation of
immature T cells with hallmarks of differentiation blockage and expansive proliferation. The …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive lymphoid neoplasm resulting
from the malignant transformation of T-cell progenitors. T-ALL leukemogenesis is strongly …

Cancer onset and progression involves the accumulation of multiple oncogenic hits, which
are thought to dominate or bypass the physiologic regulatory mechanisms in tissue …

Background: Evasion of drug and immune response in therapy-resistant leukemic stem cells
(LSCs) is a major cause of relapse. A previous study has identified an alternative …

Intratumoral accumulation of CD4+ CD25+ Foxp3+ regulatory T (Treg) cells occurs in acute
myeloid leukemia (AML), but little is known about the role of tumor cells themselves in this …

In T cell development, a pivotal decision-making stage, termed β-selection, integrates a
TCRβ checkpoint to coordinate survival, proliferation and differentiation to an αβ T cell. Here …

ABSTRACT T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic
cancer derived from the malignant transformation of T-cell progenitors. Outcomes remain …

Background Phenotypic exhaustion of CD4+ T-cells is a strong negative prognostic factor in
acute lymphoblastic leukemia (ALL). 1–3 Despite this, PD1/PD-L1 immune checkpoint …

T-cell acute lymphoblastic leukemia (T-ALL) is frequently characterized by glucocorticoid
(GC) resistance, which is associated with inferior outcomes, thus highlighting the need for …

Background Unlike most solid tumors, the incidence of TP53 aberrations in ALL is only 3%
at diagnosis. However, in relapsed ALL this number increases to 12%. More importantly, at …