Introduction The persistent inflammation that characterizes COPD and affects its natural
course also impacting on symptoms has prompted research to find molecules that can …

Inflammation is a protective reaction of the body against injury or infection, in which the
affected area becomes swollen, hot, red, and painful. In the past, it was believed that this …

CNI-1493 is a potent anti-inflammatory agent, which deactivates macrophages and inhibits
the synthesis of proinflammatory mediators. The objective of the present study was to identify …

The overproduction of TNF and other cytokines is associated with the pathophysiology of
numerous diseases. Controlling cytokine synthesis and release is critical for preventing …

We tested two novel bifunctional compounds: ibuprofen-N-octyl-pyridostigmine bromide
(IBU-PO) and ibuprofen-N-decyl-pyridostigmine bromide (IBU-PD). They both contain a non …

Over the last 20 years, the autonomic regulation of local and systemic inflammation through
the “cholinergic anti-inflammatory pathway”[1] has been increasingly recognized as playing …

Inflammation is one of the main causes of pathologic pain. Knowledge of the molecular links
between inflammatory signals and pain-mediating neuronal signals is essential for …

Excessive activation of the immune system is prevented by anti-inflammatory mediators such
as corticosteroids and anti-inflammatory cytokines. Recently, it became clear that the brain …

Systemic inflammation elicits malaise and a negative affective state. The mechanism
underpinning the aversive component of inflammation include cerebral prostaglandin …

Nerve growth factor (NGF) is a key element of inflammatory pain. It induces hyperalgesia by
up-regulating the transcription of genes encoding receptors, ion channels, and …