General anesthetics have been used to ablate consciousness during surgery for more than
150 yr. Despite significant advances in our understanding of their molecular-level …

Novel tools in neuroscience (genetic, optical, pharmacological) are being used to advance
our understanding of the complexity and functioning of the brain, the primary target of …

Understanding the neuronal mechanism of general anesthesia both helps and benefits from
research into the neurobiological basis of consciousness. Although several theories have …

ADEQUATE surgical anesthesia must achieve three goals: immobility, amnesia, and
absence of awareness. After the evidence of anesthetic lipophilicity was presented by …

The neural mechanisms of anesthetic-induced unconsciousness have yet to be fully
elucidated, in part because of the diverse molecular targets of anesthetic agents. We …

The neural mechanisms behind anesthetic-induced behavioral changes such as loss of
consciousness, amnesia, and analgesia, are insufficiently understood, though general …

In this issue of Neuron, Bharioke et al.(2022) demonstrate that diverse general anesthetic
regimens all reversibly and selectively synchronize spontaneous activity of pyramidal …

Background Neurocognitive investigations suggest that conscious sensory perception
depends on recurrent neuronal interactions among sensory, parietal, and frontal cortical …

The neurophysiological mechanisms by which anesthetic drugs cause loss of
consciousness are poorly understood. Anesthetic actions at the molecular, cellular, and …

Anesthetics are among the most widely used drugs affecting the CNS. While we have a
reasonable understanding of the pharmacological effects of anesthetics (Brown et al., 2011) …