The complement system plays a significant role within the pathological process of C3
glomerulopathy (C3GP) and atypical hemolytic uremic syndrome (aHUS). In daily practice …

Recent work has provided new insights into the causes of C3 glomerulopathy and aHUS,
and the mechanism by which complement is dysregulated. This is of particular importance …

The advances in our understanding of the alternative pathway have emphasized that
uncontrolled hyperactivity of this pathway causes 2 distinct disorders that adversely impact …

Historically, patients with kidney diseases caused by genetic or acquired dysregulation of
the complement alternative pathway have been grouped into clinical syndromes, C3 …

Dysfunction of the alternative pathway of complement in the fluid phase results in deposition
of complement factors in the renal glomeruli. This results in glomerular injury and an …

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

Atypical hemolytic uremic syndrome and C3 glomerulopathy (dense deposit disease and C3
glomerulonephritis) are characterized as inappropriate activation of the alternative …

Background Hemolytic uremic syndrome is characterized by acute renal failure,
thrombocytopenia, and Coombs-negative hemolytic anemia. In C3 mesangial proliferative …

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) are two rare
diseases caused by dysregulated activity of the alternative pathway of complement …