Complement is part of the innate immune system and plays a fundamental role in the
clearance of immune complexes and cell debris. The main effector mechanisms of …

Atypical hemolytic uremic syndrome and C3 glomerulopathy/immune complex
membranoproliferative glomerulonephritis are ultra-rare chronic, complement-mediated …

Atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) are associated
with loss of regulation of the alternative pathway of complement and its resulting …

Abstract C3 glomerulopathy (C3G) is a clinicopathologic entity secondary to dysregulation of
the alternative complement pathway in plasma and the glomerular microenvironment. The …

Rationale & Objective C3 glomerulopathy (C3GN) and atypical hemolytic uremic syndrome
(aHUS) are 2 distinct rare kidney diseases caused by dysregulation of the alternative …

Atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) have been
linked to mutations in many of the proteins that are involved in alternative complement …

In the past 20 years, we have witnessed tremendous advances in our ability to diagnose and
treat genetic diseases of the kidney caused by complement dysregulation. Staggering …

Dysfunction of the alternative pathway of complement activation provides a pathophysiologic
link between the C3 glomerulopathies dense deposit disease and glomerulonephritis with …

C3 glomerulopathy (C3G) is a complex ultra-rare complement-mediated renal disease
caused by uncontrolled activation of the complement alternative pathway (AP) in the fluid …

Over recent years, complement has emerged as a major player in the development of a
number of glomerular diseases, including atypical haemolytic uraemic syndrome …