C3 glomerulopathy describes a spectrum of disorders with glomerular pathology associated
with C3 cleavage product deposition and with defective complement action and regulation …

Abstract C3 glomerulopathy (C3G) describes a pathologic pattern of injury diagnosed by
renal biopsy. It is characterized by the dominant deposition of the third component of …

C3 glomerulopathy has recently been described as a distinct entity. The underlying
mechanism is unregulated activation of the alternate pathway of the complement system …

Background Atypical hemolytic uremic syndrome (aHUS) is associated with mutations
affecting complement proteins and regulators and with autoantibodies against complement …

In April 2012, a group of nephrologists organized a consensus conference in Cambridge
(UK) on type II membranoproliferative glomerulonephritis and decided to use a new …

Based on new pathophysiological discoveries in recent years, a new classification of
glomerulonephritis with dominant or codominant C3 deposits was introduced in 2010, which …

Disease associated membranoproliferative glomeru‑lonephritis (MPGN) has been well‑
known for decades. Recently, advances in the understanding of the comple‑ment system …

Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease characterized by
microangiopathic hemolysis, thrombocytopenia, and renal impairment and is associated …

ABSTRACT Background: C3 glomerulopathy (C3G) is an uncommon disease characterized
by the deposition of complement factors in the glomeruli due to overactivation and …

Background Complement activation in atypical hemolytic uremic syndrome (aHUS), C3
glomerulonephropathy (C3G) and immune complex-mediated membranoproliferative …