C3 glomerulopathy (C3G) defines a group of very rare renal diseases in which dysregulation
of the alternative and terminal complement pathways plays a pivotal pathogenic role …

C3 glomerulopathy is a recent disease classification comprising several rare types of
glomerulonephritis, including dense deposit disease (DDD) and C3 glomerulonephritis …

Objectives To review the role of complement in glomerular pathologies focusing on
thrombotic microangiopathies (TMA) caused by Shiga toxin (Stx) and organ transplantation …

The diagnosis of C3G is often challenging, as it can mimic other inflammatory diseases.
Limited data on the pathogenesis of the disease further complicate its clinical management …

Dysregulation of the complement alternative pathway is involved in the pathogenesis of
several diseases, including the kidney diseases atypical hemolytic uremic syndrome (aHUS) …

Objective To describe the clinicopathological features, complement abnormalities, triggers,
treatment, and outcomes of C3 glomerulopathy. Patients and Methods A total of 114 patients …

Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by a genetic
dysregulation of the alternative complement pathway, characterized by thrombocytopenia …

Gene variants in the alternative pathway of the complement system strongly associate with
atypical hemolytic uremic syndrome (aHUS), presumably by predisposing to increased …

Background: C3 glomerulopathy is a rare disease resulting from an overactivation of the
complement alternative pathway. Although there is also evidence of terminal pathway …

The complement system (CS) has recently been recognized as a bridge between innate and
adaptive immunity that constitutes a very complex mechanism controlling the clearance of …