C3 glomerulopathy is a recently introduced pathological entity whose original definition was
glomerular pathology characterized by C3 accumulation with absent or scanty …

Background It has been suggested that C3 glomerulonephritis (C3GN) and atypical
hemolytic-uremic syndrome (a stereotypical phenotype of thrombotic microangiopathy), two …

C3 glomerulopathy is a new, recently described entity that has changed the perspective,
treatment and classification of a number of glomerular diseases. It encompasses 2 similar …

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …

Background C3 glomerulopathy often presents with a membranoproliferative
glomerulonephritis (MPGN) pattern, and is principally caused by unrestricted activation of …

C3 glomerulonephritis (C3GN) is a recently described disorder that typically results from
abnormalities in the alternative pathway (AP) of complement. Here, we describe the clinical …

Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of
complement regulation that is endemic in Cyprus. The disease is characterised by …

Genetic analyses in atypical hemolytic uremic syndrome (aHUS) and C3-glomerulopathy
(C3G) patients have provided an excellent understanding of the genetic component of the …

Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathic disorder
that may be familial or sporadic. Complement factor H (CFH), factor I, and membrane …

Abstract C3 glomerulopathy (C3G) is diagnosed by kidney biopsy, with immunofluorescence
showing isolated or dominant C3 staining, indicating hyperactivity of the alternative …