[HTML][HTML] Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission
It has been proposed that neuroinflammatory response plays an important role in the
neurovascular remodeling in the brain after stress. The goal of the present study was to …
neurovascular remodeling in the brain after stress. The goal of the present study was to …
[HTML][HTML] Proteomic analysis of mouse brain subjected to spaceflight
XW Mao, LB Sandberg, DS Gridley… - International journal of …, 2018 - mdpi.com
There is evidence that spaceflight poses acute and late risks to the central nervous system.
To explore possible mechanisms, the proteomic changes following spaceflight in mouse …
To explore possible mechanisms, the proteomic changes following spaceflight in mouse …
Possible role of a dual regulator of neuroinflammation and autophagy in a simulated space environment
S Zhao, S Pei, A Wang, Y Chen, P Zhang, B Li… - Acta Astronautica, 2021 - Elsevier
Radiation and microgravity exert different biological effects on the human brain during space
flight. Studies rarely focus on the two combined. The central nervous system (CNS) is among …
flight. Studies rarely focus on the two combined. The central nervous system (CNS) is among …
Transcriptome sequencing reveals the promotion of apoptosis and M1 polarization of microglia under simulated microgravity
H Yu, XY Jia, LN Gao, T Huyan, JJ Gou, CL Gong… - Acta Astronautica, 2024 - Elsevier
The exponential progress in the field of space science and technology has facilitated the
prolonged habitation of astronauts in the space environment. However, the neurological and …
prolonged habitation of astronauts in the space environment. However, the neurological and …
[PDF][PDF] Beyond Low-earth orbit: Characterizing immune and microRNA differentials following simulated deep spaceflight conditions in mice
Spaceflight missions can cause immune system dysfunction in astronauts with little
understanding of immune outcomes in deep space. This study assessed immune responses …
understanding of immune outcomes in deep space. This study assessed immune responses …
[HTML][HTML] Transcriptomic effects on the mouse heart following 30 days on the international space station
AL Veliz, L Mamoun, L Hughes, R Vega, B Holmes… - Biomolecules, 2023 - mdpi.com
Efforts to understand the impact of spaceflight on the human body stem from growing interest
in long-term space travel. Multiple organ systems are affected by microgravity and radiation …
in long-term space travel. Multiple organ systems are affected by microgravity and radiation …
[HTML][HTML] Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice
Y Masarapu, E Cekanaviciute, Z Andrusivova… - Nature …, 2024 - nature.com
Impairment of the central nervous system (CNS) poses a significant health risk for astronauts
during long-duration space missions. In this study, we employed an innovative approach by …
during long-duration space missions. In this study, we employed an innovative approach by …
[HTML][HTML] Mice exposed to combined chronic low-dose irradiation and modeled microgravity develop long-term neurological sequelae
Spaceflight poses many challenges for humans. Ground-based analogs typically focus on
single parameters of spaceflight and their associated acute effects. This study assesses the …
single parameters of spaceflight and their associated acute effects. This study assesses the …
Proteomic analysis of mice hippocampus in simulated microgravity environment
P Sarkar, S Sarkar, V Ramesh, BE Hayes… - Journal of proteome …, 2006 - ACS Publications
Space travel induces many deleterious effects on the flight crew due to the '0'g environment.
The brain experiences a tremendous fluid shift, which is responsible for many of the …
The brain experiences a tremendous fluid shift, which is responsible for many of the …
[HTML][HTML] Time-course adaptive changes in hippocampal transcriptome and synaptic function induced by simulated microgravity associated with cognition
R Liang, L Wang, Q Yang, Q Xu, S Sun… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Methods Behavioral tests, electrophysiological recording, and RNA sequencing were used
to observe differences in behavior, synaptic plasticity, and gene expression. Results Initially …
to observe differences in behavior, synaptic plasticity, and gene expression. Results Initially …