[HTML][HTML] Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission

JM Holley, S Stanbouly, MJ Pecaut, JS Willey, M Delp… - npj …, 2022 - nature.com
It has been proposed that neuroinflammatory response plays an important role in the
neurovascular remodeling in the brain after stress. The goal of the present study was to …

[HTML][HTML] Proteomic analysis of mouse brain subjected to spaceflight

XW Mao, LB Sandberg, DS Gridley… - International journal of …, 2018 - mdpi.com
There is evidence that spaceflight poses acute and late risks to the central nervous system.
To explore possible mechanisms, the proteomic changes following spaceflight in mouse …

Possible role of a dual regulator of neuroinflammation and autophagy in a simulated space environment

S Zhao, S Pei, A Wang, Y Chen, P Zhang, B Li… - Acta Astronautica, 2021 - Elsevier
Radiation and microgravity exert different biological effects on the human brain during space
flight. Studies rarely focus on the two combined. The central nervous system (CNS) is among …

Transcriptome sequencing reveals the promotion of apoptosis and M1 polarization of microglia under simulated microgravity

H Yu, XY Jia, LN Gao, T Huyan, JJ Gou, CL Gong… - Acta Astronautica, 2024 - Elsevier
The exponential progress in the field of space science and technology has facilitated the
prolonged habitation of astronauts in the space environment. However, the neurological and …

[PDF][PDF] Beyond Low-earth orbit: Characterizing immune and microRNA differentials following simulated deep spaceflight conditions in mice

AM Paul, M Cheng-Campbell, EA Blaber, S Anand… - Iscience, 2020 - cell.com
Spaceflight missions can cause immune system dysfunction in astronauts with little
understanding of immune outcomes in deep space. This study assessed immune responses …

[HTML][HTML] Transcriptomic effects on the mouse heart following 30 days on the international space station

AL Veliz, L Mamoun, L Hughes, R Vega, B Holmes… - Biomolecules, 2023 - mdpi.com
Efforts to understand the impact of spaceflight on the human body stem from growing interest
in long-term space travel. Multiple organ systems are affected by microgravity and radiation …

[HTML][HTML] Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

Y Masarapu, E Cekanaviciute, Z Andrusivova… - Nature …, 2024 - nature.com
Impairment of the central nervous system (CNS) poses a significant health risk for astronauts
during long-duration space missions. In this study, we employed an innovative approach by …

[HTML][HTML] Mice exposed to combined chronic low-dose irradiation and modeled microgravity develop long-term neurological sequelae

EG Overbey, AM Paul, WA da Silveira… - International journal of …, 2019 - mdpi.com
Spaceflight poses many challenges for humans. Ground-based analogs typically focus on
single parameters of spaceflight and their associated acute effects. This study assesses the …

Proteomic analysis of mice hippocampus in simulated microgravity environment

P Sarkar, S Sarkar, V Ramesh, BE Hayes… - Journal of proteome …, 2006 - ACS Publications
Space travel induces many deleterious effects on the flight crew due to the '0'g environment.
The brain experiences a tremendous fluid shift, which is responsible for many of the …

[HTML][HTML] Time-course adaptive changes in hippocampal transcriptome and synaptic function induced by simulated microgravity associated with cognition

R Liang, L Wang, Q Yang, Q Xu, S Sun… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Methods Behavioral tests, electrophysiological recording, and RNA sequencing were used
to observe differences in behavior, synaptic plasticity, and gene expression. Results Initially …