Spaceflight missions can cause immune system dysfunction in astronauts with little
understanding of immune outcomes in deep space. This study assessed immune responses …

As we explore other planetary bodies, astronauts will face unique environmental and
physiological challenges. The human immune system has evolved under Earth's …

Introduction Spaceflight leads to the deconditioning of multiple body systems including the
immune system. We sought to characterize the molecular response involved by capturing …

Exposure to microgravity (µG) during space flights produces a state of immunosuppression,
leading to increased viral shedding, which could interfere with long term missions. However …

Background: It is currently unknown whether immune system alterations persist during long-
duration spaceflight. In this study various adaptive immune parameters were assessed in …

Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

Although we have sent humans into space for more than 50 years, crucial questions
regarding immune response in space conditions remain unanswered. There are many …

Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …

Recent data indicates that dysregulation of the immune system occurs and persists during
spaceflight. Impairment of immunity, especially in conjunction with elevated radiation …

Spaceflight and terrestrial spaceflight analogs can alter immune phenotypes. Macrophages
are important immune cells that bridge the innate and adaptive immune systems and …