Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including
collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in …

Detailed analysis of the cellular and molecular mechanisms that mediate liver fibrosis has
provided a framework for therapeutic approaches to prevent, slow down, or even reverse …

Fibrogenesis represents the main pathophysiological consequence of chronic liver disease
and leads to life-threatening clinical consequences. The knowledge in this field has grown …

The pathogenesis of hepatic fibrosis involves significant deposition of fibrilar collagen and
other extracellular matrix proteins. It is a rather dynamic process of wound healing in …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Liver fibrosis is a serious health problem worldwide, which can be induced by a wide
spectrum of chronic liver injuries. However, until today, there is no effective therapy available …

There has been tremendous progress made in understanding the pathogenesis of hepatic
fibrosis, which has created new opportunities for the treatment of this condition. Clinical …

The understanding of hepatic fibrosis has expanded dramatically in recent years, leading to
realistic hopes for treating this scarring response to chronic liver disease. Hepatic fibrosis …