Structure and function of cationic and ionizable lipids for nucleic acid delivery
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and
become major health issues, but the treatment development remains challenging. Gene …
become major health issues, but the treatment development remains challenging. Gene …
The role of lipid components in lipid nanoparticles for vaccines and gene therapy
CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
[HTML][HTML] Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery
M Cárdenas, RA Campbell, MY Arteta… - Current Opinion in …, 2023 - Elsevier
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems,
notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined …
notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined …
Lipid nanoparticle–mRNA formulations for therapeutic applications
Conspectus After decades of extensive fundamental studies and clinical trials, lipid
nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and …
nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and …
Looking back, moving forward: Lipid nanoparticles as a promising frontier in gene delivery
D Pozzi, G Caracciolo - ACS Pharmacology & Translational …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) have shown remarkable success in delivering genetic materials
like COVID-19 LNP vaccines, such as mRNA-1273/SpikeVax by Moderna and …
like COVID-19 LNP vaccines, such as mRNA-1273/SpikeVax by Moderna and …
Cationic lipid-mediated nucleic acid delivery: beyond being cationic
NM Rao - Chemistry and Physics of Lipids, 2010 - Elsevier
Realization of the potential of nucleic acids as drugs is intricately linked to their in vivo
delivery. Cationic lipids demonstrated tremendous potential as safe, efficient and scalable in …
delivery. Cationic lipids demonstrated tremendous potential as safe, efficient and scalable in …
Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement
R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …
[HTML][HTML] Lipid nanoparticles for mRNA delivery
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
Chemistry of lipid nanoparticles for RNA delivery
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics
H Mukai, K Ogawa, N Kato, S Kawakami - Drug metabolism and …, 2022 - Elsevier
Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics,
including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease …
including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease …
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