Structure and function of cationic and ionizable lipids for nucleic acid delivery

D Sun, ZR Lu - Pharmaceutical Research, 2023 - Springer
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and
become major health issues, but the treatment development remains challenging. Gene …

The role of lipid components in lipid nanoparticles for vaccines and gene therapy

CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …

[HTML][HTML] Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery

M Cárdenas, RA Campbell, MY Arteta… - Current Opinion in …, 2023 - Elsevier
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems,
notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined …

Lipid nanoparticle–mRNA formulations for therapeutic applications

C Wang, Y Zhang, Y Dong - Accounts of chemical research, 2021 - ACS Publications
Conspectus After decades of extensive fundamental studies and clinical trials, lipid
nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and …

Looking back, moving forward: Lipid nanoparticles as a promising frontier in gene delivery

D Pozzi, G Caracciolo - ACS Pharmacology & Translational …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) have shown remarkable success in delivering genetic materials
like COVID-19 LNP vaccines, such as mRNA-1273/SpikeVax by Moderna and …

Cationic lipid-mediated nucleic acid delivery: beyond being cationic

NM Rao - Chemistry and Physics of Lipids, 2010 - Elsevier
Realization of the potential of nucleic acids as drugs is intricately linked to their in vivo
delivery. Cationic lipids demonstrated tremendous potential as safe, efficient and scalable in …

Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement

R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

[HTML][HTML] Lipid nanoparticles for mRNA delivery

X Hou, T Zaks, R Langer, Y Dong - Nature Reviews Materials, 2021 - nature.com
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …

Chemistry of lipid nanoparticles for RNA delivery

Y Eygeris, M Gupta, J Kim, G Sahay - Accounts of chemical …, 2021 - ACS Publications
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …

Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics

H Mukai, K Ogawa, N Kato, S Kawakami - Drug metabolism and …, 2022 - Elsevier
Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics,
including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease …