Host genetics in malaria: lessons from mouse studies

HM Huang, BJ McMorran, SJ Foote, G Burgio - Mammalian Genome, 2018 - Springer
Malaria remains a deadly parasitic disease caused by Plasmodium, claiming almost half a
million lives every year. While parasite genetics and biology are often the major targets in …

Susceptibility to malaria as a complex trait: big pressure from a tiny creature

A Fortin, MM Stevenson, P Gros - Human molecular genetics, 2002 - academic.oup.com
Malaria, which is a major infectious disease worldwide, is caused by the Plasmodium
parasite, one of the longest-known parasites infecting humans. The malaria situation is …

Host resistance to malaria: using mouse models to explore the host response

R Longley, C Smith, A Fortin, J Berghout… - Mammalian …, 2011 - Springer
Malaria is a disease that infects over 500 million people, causing at least 1 million deaths
every year, with the majority occurring in developing countries. The current antimalarial …

Phenotypic analysis of rodent malaria parasite asexual and sexual blood stages and mosquito stages

ASI Aly, G Deveci, I Yilmaz, A Abraham… - JoVE (Journal of …, 2019 - jove.com
Recent advances in genetics and systems biology technologies have promoted our
understanding of the biology of malaria parasites on the molecular level. However, effective …

Humanized mouse models for the study of human malaria parasite biology, pathogenesis, and immunity

NK Minkah, C Schafer, SHI Kappe - Frontiers in immunology, 2018 - frontiersin.org
Malaria parasite infection continues to inflict extensive morbidity and mortality in resource-
poor countries. The insufficiently understood parasite biology, continuously evolving drug …

Malaria infections: what and how can mice teach us

V Zuzarte-Luis, MM Mota, AM Vigário - Journal of immunological methods, 2014 - Elsevier
Malaria imposes a horrific public health burden–hundreds of millions of infections and
millions of deaths–on large parts of the world. While this unacceptable health burden and its …

Molecular evolution and phylogenetics of rodent malaria parasites

RS Ramiro, SE Reece, DJ Obbard - BMC evolutionary biology, 2012 - Springer
Background Over the last 6 decades, rodent Plasmodium species have become key model
systems for understanding the basic biology of malaria parasites. Cell and molecular …

CRISPR/Cas9 gene editing to make conditional mutants of human malaria parasite P. falciparum

HM Kudyba, DW Cobb, A Florentin… - JoVE (Journal of …, 2018 - jove.com
Malaria is a significant cause of morbidity and mortality worldwide. This disease, which
primarily affects those living in tropical and subtropical regions, is caused by infection with …

Coevolutionary Genetics of Plasmodium Malaria Parasites and Their Human Hosts1

AG Evans, TE Wellems - Integrative and Comparative Biology, 2002 - academic.oup.com
Malaria has been invoked, perhaps more than any other infectious disease, as a force for
the selection of human genetic polymorphisms. Evidence for genome-shaping interactions …

Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes

M Hernandez-Valladares, P Rihet… - Physiological …, 2014 - journals.physiology.org
There is growing evidence for human genetic factors controlling the outcome of malaria
infection, while molecular basis of this genetic control is still poorly understood. Case-control …