Host genetics in malaria: lessons from mouse studies
HM Huang, BJ McMorran, SJ Foote, G Burgio - Mammalian Genome, 2018 - Springer
Malaria remains a deadly parasitic disease caused by Plasmodium, claiming almost half a
million lives every year. While parasite genetics and biology are often the major targets in …
million lives every year. While parasite genetics and biology are often the major targets in …
Susceptibility to malaria as a complex trait: big pressure from a tiny creature
A Fortin, MM Stevenson, P Gros - Human molecular genetics, 2002 - academic.oup.com
Malaria, which is a major infectious disease worldwide, is caused by the Plasmodium
parasite, one of the longest-known parasites infecting humans. The malaria situation is …
parasite, one of the longest-known parasites infecting humans. The malaria situation is …
Host resistance to malaria: using mouse models to explore the host response
Malaria is a disease that infects over 500 million people, causing at least 1 million deaths
every year, with the majority occurring in developing countries. The current antimalarial …
every year, with the majority occurring in developing countries. The current antimalarial …
Phenotypic analysis of rodent malaria parasite asexual and sexual blood stages and mosquito stages
Recent advances in genetics and systems biology technologies have promoted our
understanding of the biology of malaria parasites on the molecular level. However, effective …
understanding of the biology of malaria parasites on the molecular level. However, effective …
Humanized mouse models for the study of human malaria parasite biology, pathogenesis, and immunity
Malaria parasite infection continues to inflict extensive morbidity and mortality in resource-
poor countries. The insufficiently understood parasite biology, continuously evolving drug …
poor countries. The insufficiently understood parasite biology, continuously evolving drug …
Malaria infections: what and how can mice teach us
Malaria imposes a horrific public health burden–hundreds of millions of infections and
millions of deaths–on large parts of the world. While this unacceptable health burden and its …
millions of deaths–on large parts of the world. While this unacceptable health burden and its …
Molecular evolution and phylogenetics of rodent malaria parasites
Background Over the last 6 decades, rodent Plasmodium species have become key model
systems for understanding the basic biology of malaria parasites. Cell and molecular …
systems for understanding the basic biology of malaria parasites. Cell and molecular …
CRISPR/Cas9 gene editing to make conditional mutants of human malaria parasite P. falciparum
HM Kudyba, DW Cobb, A Florentin… - JoVE (Journal of …, 2018 - jove.com
Malaria is a significant cause of morbidity and mortality worldwide. This disease, which
primarily affects those living in tropical and subtropical regions, is caused by infection with …
primarily affects those living in tropical and subtropical regions, is caused by infection with …
Coevolutionary Genetics of Plasmodium Malaria Parasites and Their Human Hosts1
AG Evans, TE Wellems - Integrative and Comparative Biology, 2002 - academic.oup.com
Malaria has been invoked, perhaps more than any other infectious disease, as a force for
the selection of human genetic polymorphisms. Evidence for genome-shaping interactions …
the selection of human genetic polymorphisms. Evidence for genome-shaping interactions …
Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes
M Hernandez-Valladares, P Rihet… - Physiological …, 2014 - journals.physiology.org
There is growing evidence for human genetic factors controlling the outcome of malaria
infection, while molecular basis of this genetic control is still poorly understood. Case-control …
infection, while molecular basis of this genetic control is still poorly understood. Case-control …