Natural killer cells and their therapeutic role in pancreatic cancer: A systematic review

JRM Van Audenaerde, G Roeyen, PK Darcy… - Pharmacology & …, 2018 - Elsevier
Pancreatic cancer is among the three deadliest cancers worldwide with the lowest 5-year
survival of all cancers. Despite all efforts, therapeutic improvements have barely been made …

Local immune mechanisms in inflammatory bowel disease and colorectal carcinoma: natural killer cells and their activity

PR Gibson, DP Jewell - Gastroenterology, 1986 - Elsevier
Mononuclear cell (MNC) populations isolated from intestinal mucosa, mesenteric lymph
nodes, and peripheral blood have been assessed for their natural killer (NK)(Leu-7+) cell …

Natural killer cells infiltrating human nonsmall‐cell lung cancer are enriched in CD56brightCD16 cells and display an impaired capability to kill tumor cells

P Carrega, B Morandi, R Costa, G Frumento, G Forte… - Cancer, 2008 - Wiley Online Library
BACKGROUND. Despite natural killer (NK) cells being originally identified and named
because of their ability to kill tumor cells in vitro, only limited information is available on NK …

[HTML][HTML] Therapeutic potential of natural killer cells in gastric cancer

Y Du, Y Wei - Frontiers in immunology, 2019 - frontiersin.org
Gastric cancer (GC) is one of the most common cancers, with a high incidence of cancer
death. Despite various therapeutic approaches, the cures and prognosis of advanced GC …

[HTML][HTML] Activity of IL-12/15/18 primed natural killer cells against hepatocellular carcinoma

L Zhuang, RJ Fulton, P Rettman, AE Sayan… - Hepatology …, 2019 - Springer
Background Hepatocellular carcinoma (HCC) is common, but remains difficult to treat.
Natural killer (NK) cells are cells of the innate immune system that have potent anti-cancer …

[HTML][HTML] NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis

S Nersesian, SL Schwartz, SR Grantham… - Translational …, 2021 - Elsevier
The immune landscape of a tumor is highly connected to patient prognosis and response to
treatment, but little is known about how natural killer (NK) cells predict overall survival (OS) …

[HTML][HTML] Intratumor regulatory noncytotoxic NK cells in patients with hepatocellular carcinoma

A Zecca, V Barili, D Rizzo, A Olivani, E Biasini… - Cells, 2021 - mdpi.com
Previous studies support the role of natural killer (NK) cells in controlling hepatocellular
carcinoma (HCC) progression. However, ambiguity remains about the multiplicity and the …

Natural killer cells in cancer and cancer immunotherapy

H Raskov, A Orhan, A Salanti, S Gaggar, I Gögenur - cancer letters, 2021 - Elsevier
The detection and killing of neoplastic cells require coordination of a variety of antitumor
effector cells. Natural killer (NK) cells of the innate immune system are at the forefront of the …