Pulmonary surfactant is a heterogeneous combination of lipids and proteins, which prevents
alveolar collapse at the end of expiration cycle by decreasing the alveolar surface tension at …

Background: Childhood interstitial lung diseases (chILD) include a large spectrum of
diseases. Besides the genetically defined surfactant dysfunction disorders, most present …

Mutations in the genes encoding the surfactant proteins B and C (SP-B and SP-C) and the
phospholipid transporter, ABCA3, are associated with respiratory distress and interstitial …

The pulmonary surfactant is a mixture of phospholipids and proteins synthesized, packaged,
and secreted by alveolar type II cells that lowers surface tension and prevents atelectasis at …

Pulmonary surfactant reduces surface tension at the air-liquid interface in the alveolus,
thereby maintaining lung volumes during the respiratory cycle. In premature newborn …

Pulmonary surfactant is a unique mixture of lipids and specific proteins that reduces surface
tension at the air-liquid interface, preventing collapse of the lung at the end of expiration …

Introduction: Surfactant function disorders are an increasingly recognized cause of pediatric
interstitial lung disease. With improvements in genetic analysis speed and accuracy, these …

Single gene disorders disrupting surfactant metabolism and resulting in acute and chronic
lung disease have been identified in recent years. This review focuses on lung disease …

Surfactant has been an important focus in pediatrics since the recognition of surfactant
deficiency in premature infants (1). It seemed logical that derangements in this system could …

Inherited disorders of pulmonary surfactant-associated proteins are rare but provide
important insights into unique mechanisms of surfactant dysfunction. Recessive loss-of …