Importance Current international normalized ratio (INR) guidelines are based on trials
involving European and US populations. To our knowledge, no adequate study involving …

Background Risk factors of stroke/thromboembolism (TE) and major bleeding, and incidence
of these events in specific age categories in warfarin-treated patients with mechanical heart …

Background Thromboembolic events (TEs) are frequent after mechanical mitral valve
replacement (MVR), but their association to anticoagulation quality is unclear and has never …

Objective: To review the current guidelines and published literature in order to identify the
evidence-based international normalized ratio (INR) goal in patients with a mechanical …

Background: The burden oral anticoagulation is a limitation of mechanical valve prostheses.
Objectives: The aim of this study was to test whether patients could be safely managed with …

Objective To compare all-cause mortality and thromboembolic events in patients undergoing
surgical aortic valve replacement (sAVR) receiving anticoagulation with warfarin versus …

Introduction Low incidences of thromboembolism (TE) and bleeding in patients with
mechanical heart valves (MHV) have previously been reported. This study assesses the …

Background and Purpose: Asians may be less vulnerable to thrombotic disease than
Caucasians. Optimum international normalized ratio (INR) anticoagulant therapy guidelines …

Background: The oral administration of anticoagulants is an effective means of preventing
thromboembolic complications in patients implanted with mechanical valves. This treatment …

Background Whether low socioeconomic status (SES) is associated with increased risk of
anticoagulation-related adverse events in patients with mechanical heart valves is unknown …