Context The most common adverse effects from neurotoxic chemotherapy are chemotherapy-
induced neuropathy (CIPN), hearing loss, and tinnitus. Although associations between …

Importance Accurate, accessible predictions of posttreatment hearing loss for patients with
head and neck cancer prior to the initiation of treatment are a necessary part of informed …

Background: Cisplatin has been associated with irreversible hearing damage. Up to now,
there is no therapeutic intervention showing benefit in preventing Cisplatin-induced …

Background Definitive cisplatin-based chemoradiation is increasingly delivered as the
treatment of choice for patients with head and neck cancer. Sensorineural hearing loss is a …

Childhood, adolescent, and young adult (CAYA) cancer survivors treated with platinum-
based drugs, head or brain radiotherapy, or both have an increased risk of ototoxicity …

Cisplatin is used frequently as an antineoplastic drug in the treatment of many different
cancers. However, when used in doses over 360mg/m 2, ototoxicity may ensue, resulting in …

Objectives Platinum-based chemotherapy is effective against a variety of pediatric
malignancies. Unfortunately, the use of cisplatin and carboplatin can lead to permanent and …

Background Cisplatin is an effective chemotherapy agent against several pediatric
malignancies. One of its side effects is irreversible sensorineural hearing damage that is …

While the overall incident rate for cancer increased slightly in children ages 14 years
between 2005 and 2009, the death rate decreased by more than half and the 5-year survival …

Importance Despite advancements in cancer therapy and supportive care, childhood cancer
survivors remain at risk for chronic morbidities associated with disease and treatment, such …