[HTML][HTML] Understanding and targeting inflammation in acute myocardial infarction: an elusive goal

CB Granger, A Kochar - Journal of the American College of Cardiology, 2018 - jacc.org
have improved after acute myocardial infarction (MI) with earlier patient presentation and
widespread application of timely reperfusion therapy. However, patients with MI complicated …

Interleukin-11 attenuates infarct size and improves ventricular function in a canine heart model of ischemia/reperfusion injury

K Takeda, G Matsumiya, S Miyagawa, M Maeda… - 2009 - Am Heart Assoc
Background; Interleukin (IL)-11 is a member of IL-6 cytokine family that is clinically used in
hematopoietic disorder. We have previously reported the preconditioning effects of IL-11 …

Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart

M Obana, K Miyamoto, S Murasawa… - American Journal …, 2012 - journals.physiology.org
Activation of cardiac STAT3 by IL-6 cytokine family contributes to cardioprotection.
Previously, we demonstrated that IL-11, an IL-6 cytokine family, has the therapeutic potential …

Four cases of investigational therapy with interleukin-11 against acute myocardial infarction

M Nakagawa, Y Owada, Y Izumi, S Nonin, K Sugioka… - Heart and vessels, 2016 - Springer
We describe four cases of the patients with ST-elevation myocardial infarction (STEMI) that
were treated with interleukin-11 (IL-11), a cardioprotective cytokine. Recombinant human IL …

Low-dose dobutamine infusion and single-dose tocilizumab in acute myocardial infarction patients with high risk of cardiogenic shock development-rationale and …

J Bo Kunkel, M Frydland, S Duus Holle… - … Heart Journal: Acute …, 2023 - academic.oup.com
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding
source (s): Novo Nordisk Fonden Background Cardiogenic shock (CS) is seen in up to 10 …

Genetic deletion of interleukin-6 attenuates left ventricular dysfunction and remodeling after a reperfused myocardial infarction

A Samanta, G Cheng, A Davani, M Girgis, L Chen… - Circulation, 2014 - Am Heart Assoc
Introduction: Interleukin-6 (IL-6) is a proinflammatory cytokine, which is known to have a
close association with cardiovascular diseases. Although myocardial expression of …

Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling

P Zymek, DY Nah, M Bujak, G Ren… - Cardiovascular …, 2007 - academic.oup.com
Abstract Objective: Interleukin-10 (IL-10) exerts potent anti-inflammatory actions and
modulates matrix metalloproteinase expression. We hypothesized that endogenous IL-10 …

Interleukin‐1 receptor antagonist levels correlate with extent of myocardial loss in patients with acute myocardial infarction

G Patti, S Mega, V Pasceri, A Nusca… - … Indexed and Peer …, 2005 - Wiley Online Library
Abstract Background: Interleukin‐1 receptor antagonist (IL‐1 Ra) levels are elevated early in
patients with acute myocardial infarction (MI) and often precede release of markers of …

Interleukin-1 blockade in cardiovascular diseases: a clinical update

LF Buckley, A Abbate - European heart journal, 2018 - academic.oup.com
Abstract Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine. IL-1 was implicated
as a cardiodepressant factor in septic shock, and subsequent pre-clinical and clinical …

[HTML][HTML] Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction

HE Groot, L Al Ali, ICC van Der Horst… - Clinical research in …, 2019 - Springer
Background and aims Myocardial infarction triggers an inflammatory response involved in
cardiac repair. We studied the association of the interleukin 6 (IL-6) cascade with infarct size …