Airway submucosal gland serous cells are important sites of fluid secretion in conducting
airways. Serous cells also express the cystic fibrosis (CF) transmembrane conductance …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

Airway submucosal glands are sites of high expression of the cystic fibrosis transmembrane
conductance regulator (CFTR) Cl− channel and contribute to fluid homeostasis in the lung …

The serous acini of airway submucosal glands are important for fluid secretion in the lung.
Serous cells are also sites of expression of the cystic fibrosis transmembrane conductance …

Mucociliary clearance, driven by the engine of ciliary beating, is the primary physical airway
defense against inhaled pathogens and irritants. A better understanding of the regulation of …

Protease-activated receptor 2 (PAR2), a G protein-coupled receptor expressed in airway
epithelia and smooth muscle, plays an important role in airway inflammation. In this study …

Submucosal glands are the primary source of airway mucus, a critical component of lung
innate defenses. Airway glands are defective in cystic fibrosis (CF), showing a complete …

Airway submucosal glands contribute to airway surface liquid (ASL) composition and
volume, both important for lung mucociliary clearance. Serous acini generate most of the …

Cystic fibrosis (CF), which is caused by mutations in CFTR, affects many tissues, including
the lung. Submucosal gland serous acinar cells are primary sites of fluid secretion and …

Physical stimulation of airway surfaces evokes liquid secretion, but the events that mediate
this vital protective function are not understood. When cystic fibrosis transmembrane …