Degeneration in neuronal nuclei producing the neuromodulators acetylcholine and
norepinephrine is a hallmark of Alzheimer's disease (AD). Therapeutic interventions that …

Degeneration in neuronal nuclei producing the neuromodulators acetylcholine and
norepinephrine is a hallmark of Alzheimer's disease (AD). Therapeutic interventions that …

Increased astrocytic Ca2+ signaling related to amyloid plaques has been shown in
Alzheimer's disease mouse models, but to date no reports have characterized behaviorally …

Background Cognitive reserve allows for resilience to neuropathology, potentially through
active compensation. Here, we examine electrophysiological evidence for active …

Increased astrocytic Ca 2+ signaling has been shown in Alzheimer's disease mouse
models, but to date no reports have characterized behaviorally induced astrocytic Ca 2+ …

Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca2+
influx through membrane-resident voltage-gated Ca2+ channels (VGCCs). Also …

Alzheimer's disease is the most common neurodegenerative disease and constitute 75% of
dementia cases worldwide. Unfortunately, efficient and affordable treatments are still lacking …

Dysfunctions of network activity and functional connectivity (FC) represent early events in
Alzheimer's disease (AD), but the underlying mechanisms remain unclear. Astrocytes …

Astrocytes play crucial roles in brain homeostasis and are emerging as regulatory elements
of neuronal and synaptic physiology by responding to neurotransmitters with Ca2+ …

Ca2+ homeostasis is essential for multiple neuronal functions and thus, Ca2+
dyshomeostasis can lead to widespread impairment of cellular and synaptic signaling …