Central metabolism is a topic that has been studied for decades, and yet, this process is still
not fully understood in Escherichia coli, perhaps the most amenable and well-studied model …

Central carbon metabolism is a basic and exhaustively analyzed pathway. However, the
intrinsic robustness of the pathway might still conceal uncharacterized reactions. To test this …

Bacterial morphology is a complex trait that is highly sensitive to changes in the
environment. For heterotrophic organisms, such as Escherichia coli, increases in nutrient …

Despite remarkable progress in mapping biochemistry and gene-protein-reaction
relationships, quantitative systems-level understanding of microbial metabolism remains a …

By exploring global gene expression of Escherichia coli growing on six different carbon
sources, we discovered a striking genome transcription pattern: as carbon substrate quality …

Background Bacteria have evolved the ability to efficiently and resourcefully adapt to
changing environments. A key means by which they optimize their use of available nutrients …

Background Escherichia coli adapted to carbon-limiting conditions is generally geared for
energy-efficient carbon utilization. This includes also the efficient utilization of glucose …

Understanding the impact of gene knockouts on cellular physiology, and metabolism in
particular, is centrally important to quantitative systems biology and metabolic engineering …

Background Constraint-based models of Escherichia coli metabolic flux have played a key
role in computational studies of cellular metabolism at the genome scale. We sought to …

Evolutionary adaptation to a constant environment is often accompanied by specialization
and a reduction of fitness in other environments. We assayed the ability of the Lenski …