Background Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive
neurodegenerative disease that mainly affects the motor system. A number of potentially …

Background Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive
neurodegenerative disorder. Increasing age is an important risk factor for developing ALS …

Objective Reliable biomarkers for amyotrophic lateral sclerosis (ALS) are needed, given the
clinical heterogeneity of the disease. Here, we provide proof‐of‐concept for using …

Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper
motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and …

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

Importance of the field: With the emergence of therapeutic candidates for the incurable and
rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it …

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of upper
and lower motor neurons, with variable involvement of extramotor brain regions. Currently …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor
neurons in the cerebral cortex, brainstem, and spinal cord, brain regions in which …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise
cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate …