The role of CD8+ T cells in the process of autoimmune pathology has been both
understudied and controversial. Multiple sclerosis (MS) is an inflammatory, demyelinating …

The vast majority of studies regarding the immune basis of MS (and its animal model, EAE)
have largely focused on CD4+ T-cells as mediators and regulators of disease. Interestingly …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

Objective: To determine the antigenic determinants and specific molecular requirements for
the generation of autoregulatory neuroantigen-specific CD8+ T cells in models of multiple …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS)
characterized by plaques of infiltrating CD4+ and CD8+ T cells. Studies of MS and …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS). MS is thought to be T-cell-mediated, with prior research predominantly …

The role of CD8+ T cells in multiple sclerosis (MS) and its animal models has been
enigmatic. Most studies of MS have focused on the role of CD4+ Th1 T cells and many …

The dysregulation of inflammatory responses and of immune self-tolerance is considered to
be a key element in the autoreactive immune response in multiple sclerosis (MS) …

A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease
process in multiple sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 …

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS). Although its etiology remains unknown, pathogenic T cells are thought to …