The progress in understanding the mechanisms of T cell activation, inactivation and
modulation has been translated into different immunotherapeutic strategies aiming at …

Mechanisms underlying the clinical benefits of glatiramer acetate (GA) for patients with
multiple sclerosis (MS) remain elusive. A prevailing hypothesis is that GA can induce Th2 …

Experimental autoimmune encephalomyelitis (EAE) serves as the prototypic model for T cell–
mediated autoimmunity. EAE has striking similarities with the human disease acute …

During the last few years, the concept of multiple sclerosis (MS) as a pure inflammatory
disease mediated by myelin reactive T cells has been challenged. Neither the specificity nor …

Objective The objective of this study was to investigate the role of CD8+ CD25+ FoxP3+
cells during the course of multiple sclerosis (MS). Methods Peripheral blood and …

Multiple sclerosis (MS) is a CNS autoimmune disease believed to be triggered by T cells
secreting Th1-specific proinflammatory cytokines, such as GM-CSF. In the animal model of …

Impaired suppressive function of CD4+ CD25high regulatory T cells (Treg) has been
reported as a novel pathogenetic mechanism in Multiple sclerosis (MS). We addressed if …

Multiple sclerosis (MS) is a neurodegenerative autoimmune disease characterized by the
destruction of the myelin sheath of the neuronal axon in the central nervous system. Many …

Increasing evidence suggests an important role of CD8+ cells in the pathogenesis of
multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) …

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is
believed to be immune-mediated. While CD4+ T cells have been the main suspects for …