Frailty is the hallmark of aging that can be delayed with exercise. The present studies were
initiated based on the hypothesis that long-term voluntary wheel running (VWR) in female …

Objective Age-related loss of muscle mass and function can be attenuated in rodents with
life-long voluntary wheel running with moderate resistance. The present study assessed if …

The purpose of this study was to investigate whether long-term wheel running would
attenuate age-related loss of muscle fiber. Male ICR mice were divided into young (Y, n= 12 …

The senescence-accelerated mouse prone 8 (SAMP8) is considered a useful non-
transgenic model for studying aspects of aging. Using SAM resistant 1 (SAMR1) as controls …

Decreased skeletal muscle performance with increasing age is strongly associated with
reduced mobility and quality of life. Increased physical activity is a widely prescribed method …

Laboratory mice of both sexes having free access to running wheels are commonly used to
study mechanisms underlying the beneficial effects of physical exercise on health and aging …

Exercise has been shown to improve physical function, mitigate aspects of chronic disease
and to potentially alter the trajectory of age-related onset of frailty and sarcopenia. Reliable …

This study compared the capacity of young and old male C57Bl/6J mice to exercise with
increasing resistance over 10 weeks, and its impact on muscle mass. Young mice (aged 15 …

Both physical activity and body mass affect bone properties. In this study we examined how
diet-induced obesity combined with voluntary physical activity affects bone properties. Forty …

One of the most important strategies for successful aging is exercise. However, the effect of
exercise can differ among individuals, even with exercise of the same type and intensity …