[HTML][HTML] G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

D Jacenik, EJ Beswick, WM Krajewska… - World Journal of …, 2019 - ncbi.nlm.nih.gov
Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …

Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer

Q Liu, Z Chen, G Jiang, Y Zhou, X Yang, H Huang… - Molecular cancer, 2017 - Springer
Background Estrogenic signals are suggested to have protection roles in the development of
colorectal cancer (CRC). The G protein-coupled estrogen receptor (GPER) has been …

[HTML][HTML] Significance of G protein-coupled estrogen receptor in the pathophysiology of irritable bowel syndrome, inflammatory bowel diseases and colorectal cancer

D Jacenik, WM Krajewska - Frontiers in Endocrinology, 2020 - frontiersin.org
The regulatory role of estrogens and nuclear estrogen receptors, ie, estrogen receptor α and
β has been reported in gastrointestinal diseases. However, the contribution of G protein …

The G protein-coupled estrogen receptor as a modulator of neoplastic transformation

D Jacenik, AI Cygankiewicz, WM Krajewska - Molecular and cellular …, 2016 - Elsevier
Estrogens play a crucial role in the regulation of physiological and pathophysiological
processes. These hormones act through specific receptors, most notably the canonical …

Implications of estrogen and its receptors in colorectal carcinoma

PK Das, J Saha, S Pillai, AKY Lam, V Gopalan… - Cancer …, 2023 - Wiley Online Library
Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

Role of G protein-coupled estrogen receptor in cancer progression

J Jung - Toxicological research, 2019 - Springer
Cancer is the leading cause of mortality worldwide. In cancer progression, sex hormones
and their receptors are thought to be major factors. Many studies have reported the effects of …

G protein-coupled estrogen receptor (GPER) expression in endometrial adenocarcinoma and effect of agonist G-1 on growth of endometrial adenocarcinoma cell lines

M Skrzypczak, S Schüler, C Lattrich, A Ignatov… - Steroids, 2013 - Elsevier
The G protein-coupled estrogen receptor (GPER, GPR30) is suggested to be involved in non-
nuclear estrogen signaling and is expressed in a variety of hormone dependent cancer …

The roles of estrogen and estrogen receptors in gastrointestinal disease

C Chen, X Gong, X Yang, X Shang… - Oncology …, 2019 - spandidos-publications.com
Estrogen is an important sex steroid hormone which serves an important role in the
regulation of a number of biological functions, including regulating bone density, brain …

G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis

T Wei, W Chen, L Wen, J Zhang, Q Zhang, J Yang… - Cancer letters, 2016 - Elsevier
G protein-coupled estrogen receptor (GPER) is a novel estrogen-binding receptor involved
in many pathological conditions, including cancer. In this study, we investigated the effect of …

A novel estrogen receptor GPER mediates proliferation induced by 17β‐estradiol and selective GPER agonist G‐1 in estrogen receptor α (ERα)‐negative ovarian …

H Liu, Y Yan, H Wen, X Jiang, X Cao… - Cell Biology …, 2014 - Wiley Online Library
G protein‐coupled estrogen receptor (GPER) is recently identified as a membrane‐
associated estrogen receptor that mediates non‐genomic effects of estrogen. Our previous …