Clinical evidence suggests that estradiol replacement therapy reduces colon cancer risk in
'post'menopausal women. In colon epithelial cells, the estrogen receptor β (ERβ) is the …

Biological responses to estrogens in normal and malignant tissues are mainly mediated by
the estrogen receptors ERα and ERβ, which function as ligand-activated transcription …

GPER is a membrane-associated estrogen receptor of the family of G-protein coupled
receptors. For breast cancer, the contribution of GPER to promoting the proliferation and …

Endometrial carcinoma is the most common cancer of the female reproductive tract.
GPER/GPR30 is a 7‐transmembrane spanning G protein‐coupled receptor that has been …

AIM: To determine the expression of estrogen receptor (ER) β in Chinese colorectal
carcinoma (CRC) patients. METHODS: ERβ expression in CRC was investigated by …

Epidemiological studies show that oestrogen reduces the risk of colorectal cancer in
postmenopausal women and ERβ (oestrogen receptor β)-selective ligands have been …

Results In gastric cancer, ER were detected in 62.5% and PR in 75% of the patients. In
colorectal cancer, the ER and PR were detected in 60% of the patients. The binding activity …

In 2005, two groups independently discovered that the G protein-coupled receptor GPR30
binds estradiol in cultured cells and, in response, initiates intracellular signaling cascades …

Estrogen is a kind of steroid compound that has extensive biologic activities. The effect of
estrogen is pleiotropic, affecting multiple systems in the body. There is accumulating …

Postmenopausal women on estrogen replacement therapy (ERT) have a reduced risk of
developing colon cancer compared with postmenopausal women not on ERT, suggesting a …