Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ …

DM Absher, X Li, LL Waite, A Gibson, K Roberts… - PLoS …, 2013 - journals.plos.org
Systemic lupus erythematosus (SLE) is an autoimmune disease with known genetic,
epigenetic, and environmental risk factors. To assess the role of DNA methylation in SLE, we …

Genome-wide DNA methylation patterns in CD4+ T cells from Chinese Han patients with rheumatoid arthritis

S Guo, Q Zhu, T Jiang, R Wang, Y Shen… - Modern …, 2017 - academic.oup.com
Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic
inflammation of the joints. Recent evidence indicated the epigenetic changes may contribute …

DNA methylation in systemic lupus erythematosus

CM Hedrich, K Mäbert, T Rauen, GC Tsokos - Epigenomics, 2017 - Taylor & Francis
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by
aberrant immune responses directed against cells and tissues, resulting in inflammation and …

DNA methylome signature in rheumatoid arthritis

K Nakano, JW Whitaker, DL Boyle, W Wang… - Annals of the …, 2013 - ard.bmj.com
Objectives Epigenetics can influence disease susceptibility and severity. While DNA
methylation of individual genes has been explored in autoimmunity, no unbiased systematic …

Exploration of biomarkers of psoriasis through combined multiomics analysis

L Xing, T Wu, L Yu, N Zhou, Z Zhang… - Mediators of …, 2022 - Wiley Online Library
Background. Aberrant DNA methylation patterns are of increasing interest in the study of
psoriasis mechanisms. This study aims to screen potential diagnostic indicators affected by …

Increased 5-hydroxymethylcytosine in CD4+ T cells in systemic lupus erythematosus

M Zhao, J Wang, W Liao, D Li, M Li, H Wu… - Journal of …, 2016 - Elsevier
One of the major disappointments in autoimmunity has been the relative lack of informative
data when genomewide associations (GWAS) have been applied to patients with systemic …

Overlap between differentially methylated DNA regions in blood B lymphocytes and genetic at-risk loci in primary Sjögren's syndrome

C Miceli-Richard, SF Wang-Renault… - Annals of the …, 2016 - ard.bmj.com
Background Beyond genetics, epigenetics alterations and especially those related to DNA
methylation, play key roles in the pathogenesis of autoimmune diseases such as primary …

Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: identifying DNA methylation signatures associated with …

S Joseph, NI George, B Green-Knox, EL Treadwell… - Journal of …, 2019 - Elsevier
Systemic lupus erythematosus (SLE or lupus) is a heterogeneous autoimmune disease
characterized by the involvement of multiple organs and the production of antinuclear …

Genome-wide DNA methylation patterns in monocytes derived from patients with primary Sjogren syndrome

X Luo, Y Peng, YY Chen, AQ Wang… - Chinese Medical …, 2021 - mednexus.org
Background: Epigenetics, especially DNA methylation, plays an important role in the
pathogenesis of primary Sjogren syndrome (pSS). Our study aimed to reveal the role of DNA …

Genome-wide analysis of 5-hmC in the peripheral blood of systemic lupus erythematosus patients using an hMeDIP-chip

W Sui, Q Tan, M Yang, Q Yan… - International …, 2015 - spandidos-publications.com
Systemic lupus erythematosus (SLE) is a chronic, potentially fatal systemic autoimmune
disease characterized by the production of autoantibodies against a wide range of self …