Objective Maladaptive repair contributes towards the development of heart failure following
myocardial infarction (MI). The αvβ3 integrin receptor is a key mediator and determinant of …

Aims The purpose of this study was to determine the feasibility of a new positron emission
tomography (PET) imaging approach using an 18F-labelled αvβ3 integrin antagonist (18F …

18F-galacto-RGD (18F-RGD) is a PET tracer binding to αvβ3 integrin receptors that are
upregulated after myocardial infarction (MI) as part of the healing process. We studied …

Objectives Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis
and are mediated by the alpha-V beta-3 (αvβ3) integrin pathway. We investigated the …

A 35-year-old Caucasian male presented with chest pain and nausea in the emergency
room. The initial ECG displayed sinus-rhythm with ST elevation in I, aVL, V1–5, ST …

Purpose Increased angiogenesis after myocardial infarction is considered an important
favorable prognostic parameter. The αvβ3 integrin is a key mediator of cell-cell and cell …

Background—Integrins are involved in structural remodeling and tissue repair. This study
aimed to elucidate the role of the β-integrins in cardiac remodeling after myocardial …

Cardiac fibroblasts and myofibroblasts are responsible for post-MI remodeling which occurs
via regulation of extracellular matrix (ECM). Accelerated post-MI remodeling leads to …

There is currently no therapy to limit the development of cardiac fibrosis and consequent
heart failure. We have recently shown that cardiac fibrosis post-myocardial infarction (MI) …

Objective: To study the role of β1 integrins in left ventricular (LV) remodelling after
myocardial infarction (MI). Methods and results: LV structural and functional alterations were …