Aim To understand the role of the collagen‐binding integrin α11 in vivo, we have used a
classical approach of creating a mouse strain overexpressing integrin α11. A transgenic …

Background—Fibrosis and progressive failure are prominent pathophysiological features of
hearts after myocardial infarction (MI). We examined the effects of inhibiting transforming …

Reperfusion injury after coronary occlusion is in part mediated by leukocyte activation and
adhesion. Platelets may interact with polymorphonuclear granulocytes (PMNs), causing …

Objectives: The purpose of this study was to investigate the role of plasminogen (Plg) in
stem cell–mediated cardiac repair and regeneration after myocardial infarction (MI) …

Noninvasively monitoring activated fibroblasts is of great value for understanding the
dynamic process of myocardial fibrosis after myocardial infarction (MI). This study aimed to …

Remodeling of the cardiac extracellular matrix (ECM) is an integral part of wound healing
and ventricular adaptation after myocardial infarction (MI), but the underlying mechanisms …

Angiogenesis is crucial to restore microvascular perfusion in the jeopardized myocardium in
the weeks following reperfused ST-segment elevation myocardial infarction (STEMI).(VEGF) …

Tissue repair following myocardial infarction (MI) eventuates in fibrous tissue formation at
the site of myocyte necrosis. Following a large transmural MI, fibrosis appears remote to the …

Heart failure remains a major source of late morbidity and mortality after myocardial
infarction (MI). The temporospatial presence of activated fibroblasts in the injured …

Insulin-like growth factor 1 (IGF1) is an anabolic hormone that controls the growth and
metabolism of many cell types. However, IGF1 also mediates cardio-protective effects after …