Angiogenesis is crucial to restore microvascular perfusion in the jeopardized myocardium in
the weeks following reperfused ST-segment elevation myocardial infarction (STEMI).(VEGF) …

Insulin-like growth factor-1 (IGF-1) has been found to exert favorable effects on
angiogenesis in prior animal studies. This study explored the long-term effect of IGF-1 on …

Background—Accumulating evidence has suggested that the cardiac renin-angiotensin
system is activated during the remodeling process after myocardial infarction (MI). Although …

Insulin-like growth factor 1 (IGF1) is an anabolic hormone that controls the growth and
metabolism of many cell types. However, IGF1 also mediates cardio-protective effects after …

Background—Myocardial ischemic injury after heart transplantation is associated with
subsequent development of graft vasculopathy. Both vitronectin receptor (integrin αvβ3) and …

Monocytes are involved in adverse left ventricular (LV) remodelling following myocardial
infarction (MI). To provide therapeutic opportunities we aimed to identify gene transcripts in …

The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

Cardiovascular diseases, including myocardial infarction and its complications such as heart
failure, are the leading cause of death worldwide. To date, basic and translational research …

Background—Noninvasive imaging strategies play a critical role in assessment of the
efficacy of angiogenesis therapies. The αvβ3 integrin is activated in angiogenic vessels and …

Adverse ventricular remodeling during the healing phase after acute myocardial infarction
(MI) continues to be an important problem that impacts adult cardiology practice. Most …