Preclinical models of myocardial infarction: from mechanism to translation

TP Martin, EA MacDonald… - British Journal of …, 2022 - Wiley Online Library
Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Guidelines for in vivo mouse models of myocardial infarction

ML Lindsey, KR Brunt, JA Kirk… - American Journal …, 2021 - journals.physiology.org
Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Animal models of myocardial infarction: Mainstay in clinical translation

M Kumar, ER Kasala, LN Bodduluru, V Dahiya… - Regulatory Toxicology …, 2016 - Elsevier
Preclinical models with high prognostic power are a prerequisite for translational research.
The closer the similarity of a model to myocardial infarction (MI), the higher is the prognostic …

[HTML][HTML] Current status and limitations of myocardial infarction large animal models in cardiovascular translational research

HS Shin, HH Shin, Y Shudo - Frontiers in bioengineering and …, 2021 - frontiersin.org
Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …

Considerations for the bioengineering of advanced cardiac in vitro models of myocardial infarction

P Sharma, X Wang, CLC Ming, L Vettori, G Figtree… - Small, 2021 - Wiley Online Library
Despite the latest advances in cardiovascular biology and medicine, myocardial infarction
(MI) remains one of the major causes of deaths worldwide. While reperfusion of the …

Rat models of myocardial infarction

R Bhindi, PK Witting, AC McMahon… - Thrombosis and …, 2006 - thieme-connect.com
Animal models of cardiovascular pathology contribute towards understanding and treatment
of a broad range of conditions. Specifically in the context of acute myocardial infarction …

Models of myocardial ischemia

K Ytrehus - Drug Discovery Today: Disease Models, 2006 - Elsevier
The heart is highly dependent on aerobic metabolism. Given the widespread occurrence of
coronary atherosclerosis in the human, myocardial ischemia is a huge clinical problem …

Guidelines for experimental models of myocardial ischemia and infarction

ML Lindsey, R Bolli, JM Canty Jr… - American Journal …, 2018 - journals.physiology.org
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Myocardial infarction and intramyocardial injection models in swine

FC McCall, KS Telukuntla, V Karantalis, VY Suncion… - Nature protocols, 2012 - nature.com
Sustainable and reproducible large animal models that closely replicate the clinical
sequelae of myocardial infarction (MI) are important for the translation of basic science …

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on …

J van der Velden, FW Asselbergs… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …