Epstein-Barr virus (EBV) is a ubiquitous human virus that promotes B-cell activation and
maturation through expression of latency proteins and non-coding RNAs. In this study, we …

ABSTRACT BFL-1 is an understudied anti-apoptotic protein upregulated in cancer and
Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines (LCLs). We have previously …

Chromatin accessibility fundamentally governs gene expression and biological response
programs that can be manipulated by pathogens. Here we capture dynamic chromatin …

Human B cells encompass functionally diverse lineages and phenotypic states that
contribute to protective as well as pathogenic responses. Epstein-Barr virus (EBV) provides …

The oncogenic gammaherpesviruses, including human Epstein-Barr virus (EBV), human
Kaposi's sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 …

Epstein–Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The
virus efficiently infects resting human B lymphocytes and induces their continuous …

Highlights•Key EBV transcription factors hijack host cell factors to reprogramme B cells.•This
is mostly directed through binding to host gene enhancers and super-enhancers.•Binding …

Highlights•EBNA2 and TET2-mediated DNA demethylation promotes latency III in B
cells.•EBNA3A/3C and polycomb prevent plasmablast differentiation driven by …

Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including
infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy …

Simple Summary Epstein–Barr virus (EBV) was first isolated in 1964 and has since become
an important human tumor virus. With an estimated 90% of the human population infected …