Low skeletal muscle mass is associated with cognitive impairment and dementia in older
adults. This review describes the possible underlying pathophysiological mechanisms …

With increasing age there is a temporal relationship between the decline of mitochondrial
and skeletal muscle volume, quality and function (ie, health). Reduced mitochondrial mRNA …

Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of
adverse outcomes, such as impaired physical performance, cognitive function, and mortality …

Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging
process. A growing body of research in the areas of bioenergetics and protein turnover has …

Age‐related loss of muscle mass and strength (sarcopenia) leads to a decline in physical
function and frailty in the elderly. Among the many proposed underlying causes of …

The role of mitochondrial dysfunction and oxidative stress has been extensively
characterized in the aetiology of sarcopenia (aging-associated loss of muscle mass) and …

Background The concept of mitochondrial dysfunction in ageing muscle is highly
controversial. In addition, emerging evidence suggests that reduced muscle oxidative …

It has been established that the impairment of mitochondrial function is associated with
various disorders, such as type 2 diabetes and Alzheimer's disease. In addition …

The relationship between the age-associated decline in mitochondrial function and its effect
on skeletal muscle physiology and function remain unclear. In the current study, we …