Pathophysiological mechanisms explaining the association between low skeletal muscle mass and cognitive function

SJ Oudbier, J Goh, SMLM Looijaard… - The Journals of …, 2022 - academic.oup.com
Low skeletal muscle mass is associated with cognitive impairment and dementia in older
adults. This review describes the possible underlying pathophysiological mechanisms …

Mitochondrial and skeletal muscle health with advancing age

AR Konopka, KS Nair - Molecular and cellular endocrinology, 2013 - Elsevier
With increasing age there is a temporal relationship between the decline of mitochondrial
and skeletal muscle volume, quality and function (ie, health). Reduced mitochondrial mRNA …

Sarcopenia and Cognitive Decline in Older Adults: Targeting the Muscle–Brain Axis

B Arosio, R Calvani, E Ferri, HJ Coelho-Junior… - Nutrients, 2023 - mdpi.com
Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

Searching for a mitochondrial root to the decline in muscle function with ageing

M Gonzalez‐Freire, F Adelnia… - Journal of cachexia …, 2018 - Wiley Online Library
Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of
adverse outcomes, such as impaired physical performance, cognitive function, and mortality …

Skeletal muscle aging and the mitochondrion

ML Johnson, MM Robinson, KS Nair - Trends in endocrinology & …, 2013 - cell.com
Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging
process. A growing body of research in the areas of bioenergetics and protein turnover has …

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high‐and low‐functioning elderly individuals

AM Joseph, PJ Adhihetty, TW Buford… - Aging cell, 2012 - Wiley Online Library
Age‐related loss of muscle mass and strength (sarcopenia) leads to a decline in physical
function and frailty in the elderly. Among the many proposed underlying causes of …

Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults

A Safdar, MJ Hamadeh, JJ Kaczor, S Raha, J Debeer… - PloS one, 2010 - journals.plos.org
The role of mitochondrial dysfunction and oxidative stress has been extensively
characterized in the aetiology of sarcopenia (aging-associated loss of muscle mass) and …

Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults

G Distefano, RA Standley, X Zhang… - Journal of Cachexia …, 2018 - Wiley Online Library
Background The concept of mitochondrial dysfunction in ageing muscle is highly
controversial. In addition, emerging evidence suggests that reduced muscle oxidative …

Age‐associated mitochondrial dysfunction in skeletal muscle: Contributing factors and suggestions for long‐term interventions

JH Huang, DA Hood - Iubmb Life, 2009 - Wiley Online Library
It has been established that the impairment of mitochondrial function is associated with
various disorders, such as type 2 diabetes and Alzheimer's disease. In addition …

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

L Grevendonk, NJ Connell, C McCrum… - Nature …, 2021 - nature.com
The relationship between the age-associated decline in mitochondrial function and its effect
on skeletal muscle physiology and function remain unclear. In the current study, we …