Discogenic low back pain (DLBP) is a multifactorial disease and associated with
intervertebral disc degeneration. Calcitonin gene-related protein (CGRP) plays a critical role …

Chronic low back pain (CLBP) has been proved to be the dominating cause of disability in
patients with lumbar degenerative diseases. Of the various etiological factors, intervertebral …

Background Calcitonin gene-related peptide (CGRP) as a mediator of microglial activation
at the transcriptional level may facilitate nociceptive signaling. Trimethylation of H3 lysine 27 …

Back pain is common and costly. Although lumbar disc degeneration has long been
regarded as a major contributor to back pain, how disc degeneration leads to back pain …

Background Lumbar disc herniation is a major cause of radicular pain, but the underlying
mechanisms remain largely unknown. Spinal activation of src-family kinases are involved in …

Background Dorsal root ganglia (DRGs) contain sensory neurons that innervate
intervertebral discs (IVDs) and may play a critical role in mediating low-back pain (LBP), but …

Background Discogenic low back pain has been shown to develop into chronic intractable
pain due to an unknown pathogenesis. To study the mechanism of discogenic pain, we …

Inhibiting Vascular Endothelial Growth Factor in Injured Intervertebral Discs Attenuates Pain-Related
Neuropeptide Expression in Dorsal Root Ganglia in Rats - PMC Back to Top Skip to main …

Purpose Lumbar disc herniation (LDH) is a frequently occurring disease with unknown
etiology, which makes treatment a challenge. The aim of this study was to analyze the effects …

Background Microglia might play an important role in nociceptive processing and
hyperalgesia by neuroinflammatory process. Mineralocorticoid receptor (MR) expressed on …