It is well known that biomaterial topography can exert a profound influence on various
cellular functions such as migration, polarization, and adhesion. With the development and …

Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

Cells interact with various nanoscaled topographical and biochemical cues in their cellular
macromolecular environment. Nanotopography recreates or mimic the cellular …

Topographical cues mimicking the extracellular matrix (ECM) have demonstrated control
over a diverse range of cellular behaviours including: initial adhesion, migration, cell growth …

Topography-driven alterations in cell morphology tremendously influence cell biological
processes, particularly stem cell differentiation. Aligned topography is known to alter the cell …

Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused
by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have …

The physiological microenvironment of the stem cell niche, including the three factors of
stiffness, topography, and dimension, is crucial to stem cell proliferation and differentiation …

Mesenchymal stem/stromal cells (MSCs) serve as essential components of regenerative
medicine. Their destiny is influenced by the interaction of the cells with the external …

Featured Application The evaluation of the behavior of cultured cells on substrates with
controlled topographies can contribute significantly to the optimization of biomaterials for …

Topographical patterning has recently attracted lots of attention in regulating cell fate,
understanding the mechanism of cell–microenvironment interactions, and solving the great …