The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

Cell adhesion, orientation and migration are influenced by surface topographies in the
micrometer and nanometer range. In this work, we demonstrate the stimulation by …

The physiochemical characteristics of a material with in vivo applications are critical for the
clinical success of the implant and regulate both cellular adhesion and differentiated cellular …

The extracellular matrix (ECM) exhibits tissue-specific topography and composition and
plays a crucial role in initiating the biochemical and biomechanical signaling required for …

There is clear, emerging evidence in the literature supporting the influence of surface
topography on various cell phenotypes.[1–5] Recent advancements in mechanobiology …

In cell–material interactions, cells use filopodia to sense external biochemical and
mechanical cues, and subsequently dictate their survival. In an effort toward understanding …

The chapter discusses the use of substrate topography to control cellular response. It details
some of the fabrication methods used to produce controlled micro-and nanotopography …

The physiological role of the actin cytoskeleton is well known: it provides mechanical
support and endogenous force generation for formation of a cell shape and for migration …

The interface between materials and cells plays a critical role in many biomedical
applications. Inspired by the hierarchical architecture of collagen, most abundant structure in …

It is well recognized that the interaction between stem cells and their physical
microenvironment plays a fundamental role in controlling cell behaviors and directing …