Background: Chemical agents such as streptozotocin (STZ) and nicotinamide (NAD) are
used in animal models of diabetes mellitus and their related consequences in the kidneys …

This work aims to investigate the therapeutic effect of ursolic acid (UA) plus insulin (In) on
diabetic nephropathy (DN) in streptozotocin (STZ)-induced T1DM rats. The experimental …

Objective The objective of this study was to evaluate the role of oxidative stress in an
experimental model of streptozotocin-induced diabetic nephropathy in rats. Materials and …

The streptozotocin (STZ)-induced diabetic mouse model has been extensively used as a
model for diabetes and diabetic nephropathy, but it is still influenced by many off-target toxic …

Nephropathy is one of the complications of diabetes mellitus in human and experimental
animals. There are various pathological renal remodeling processes leading to diabetic …

Aim.–To identify the changes of mitochondrial protein expression in diabetic renal
parenchyma and to characterize their molecular functions and biological processes in …

Hyperuricemia has been recognized as a risk factor for insulin resistance as well as one of
the factors leading to diabetic kidney disease (DKD). Since DKD is the most common cause …

Background Renal injury may develop in uncontrolled chronic hyperglycemia due to
increased oxidative stress and release of pro-inflammatory mediators, leading to diabetic …

Background: Oxidative stress and inflammation are known to play central roles in the
development of diabetic nephropathy (DN). Febuxostat is a novel non-purine xanthine …

Akita mice are a genetic model of type 1 diabetes. In the present studies, we investigated the
phenotype of Akita mice on the FVB/NJ background and examined urinary nephrin excretion …