In vivo and epidemiological data suggest a mitogenic role for estrogens (E) in colon cancer.
The presence of estrogen receptor (ER) and ER mRNA in colonie epithelium and colon …

Observational epidemiological studies and randomized trials have reported a protective
effect of estrogen and progestin therapy (EPT) on the risk of colorectal cancer but the …

Abstract Background: Cigarette smoking (smoking), hormone therapy (MHT), and folate
intake (folate) are each thought to influence colorectal cancer risk, but the underlying …

Loss of estrogen receptor β (ERβ) expression in the gut is associated with colorectal cancer
(CRC) initiation and progression. Germline single-nucleotide polymorphisms (SNP) in …

Background Although the Women's Health Initiative (WHI) trial of estrogen plus progestin in
postmenopausal women identified more overall health risks than benefits among women in …

Purpose: Previous studies have shown that estrogen prevents colon cancer in
postmenopausal women, indicating a role in colorectal cancer carcinogenesis and tumor …

Background: Epidemiologic studies evaluating associations between sex steroid hormones
and colorectal cancer risk have yielded inconsistent results. To elucidate the role of …

Background: Endogenous sex hormones may contribute to higher colorectal cancer
incidence rates in men compared with women, but despite an increased number of studies …

Raloxifene, selective estrogen receptor (ER) modulator, is not fully explored in colorectal
cancer. In the present study we,(a) investigated the effect of raloxifene on ER-positive colon …

We evaluated colorectal cancer risk associated with the duration and recency of specific
menopausal hormone therapy formulations (ie, unopposed estrogen versus estrogen plus …