Neurodegenerative diseases, such as Alzheimer′ s disease (AD), Parkinson's disease
(PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent …

Since the 1970s, when ATP was identified as a co-transmitter in sympathetic and
parasympathetic nerves, it and its active metabolite adenosine have been considered …

The nucleoside inosine is an essential metabolite for purine biosynthesis and degradation; it
also acts as a bioactive molecule that regulates RNA editing, metabolic enzyme activity, and …

Abstract Inosine (hypoxanthine 9-beta-d-ribofuranoside), a purine nucleoside with multiple
intracellular roles, also serves as an extracellular modulatory signal. On neurons, it can …

Objective To test the safety, tolerability, and urate‐elevating capability of the urate precursor
inosine taken orally or by feeding tube in people with amyotrophic lateral sclerosis (ALS) …

Rationale Inosine is a naturally occurring purine nucleoside formed by adenosine
breakdown. This nucleoside is reported to exert potent effects on memory and learning …

Inositols are sugar-like compounds that are widely distributed in nature and are a part of
membrane molecules, participating as second messengers in several cell-signaling …

Adenosine has been considered as a potential immunomodulatory and neuroprotective
agent for 30 years. Inosine, a major degradation product of adenosine, was thought …

Oxidative stress has been implicated as a core contributor to the initiation and progression of
multiple neurological diseases. Genetic and environmental factors can produce oxidative …

Background Epidemiological studies have repeatedly reported that increased serum urate
level is associated with a slower progress of Parkinson's disease (PD). The urate precursor …