Neuroimaging allows investigating the extent of neurological systems degeneration in
amyotrophic lateral sclerosis (ALS). Advanced MRI methods can detect changes related to …

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects upper
and lower motor neurons. Observational and intervention studies can be tracked using …

Advances in neuroimaging, complementing histopathological insights, have established a
multi-system involvement of cerebral networks beyond the traditional neuromuscular …

Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper
motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and …

The catastrophic system failure in amyotrophic lateral sclerosis is characterized by
progressive neurodegeneration within the corticospinal tracts, brainstem nuclei and spinal …

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive
degeneration of upper motor neurons (UMN) and lower motor neurons (LMN). While LMN …

Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) lie at
opposing ends of a clinical, genetic, and neuropathological continuum. In the last decade, it …