Spinal cord markers in ALS: diagnostic and biomarker considerations

P Bede, ALW Bokde, S Byrne, M Elamin… - Amyotrophic Lateral …, 2012 - Taylor & Francis
Despite considerable involvement of the spinal cord in amyotrophic lateral sclerosis (ALS),
current biomarker research is primarily centred on brain imaging and CSF proteomics. In …

[HTML][HTML] Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra …

M Pallebage-Gamarallage, S Foxley, RAL Menke… - BMC neuroscience, 2018 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically
heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid …

[HTML][HTML] Diagnostics of amyotrophic lateral sclerosis: up to date

I Štětkářová, E Ehler - Diagnostics, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by gradual loss of upper and lower motor neurons and their pathways, usually …

Classification of amyotrophic lateral sclerosis by brain volume, connectivity, and network dynamics

J Thome, R Steinbach, J Grosskreutz… - Human brain …, 2022 - Wiley Online Library
Emerging studies corroborate the importance of neuroimaging biomarkers and machine
learning to improve diagnostic classification of amyotrophic lateral sclerosis (ALS). While …

Biomarkers for amyotrophic lateral sclerosis

S Witzel, K Mayer, P Oeckl - Current Opinion in Neurology, 2022 - journals.lww.com
Biomarkers for amyotrophic lateral sclerosis : Current Opinion in Neurology Biomarkers for
amyotrophic lateral sclerosis : Current Opinion in Neurology Log in or Register Subscribe to …

[HTML][HTML] Amyotrophic lateral sclerosis and its mimics/variants: a comprehensive review

VS Yedavalli, A Patil, P Shah - Journal of clinical imaging science, 2018 - ncbi.nlm.nih.gov
Motor neuron diseases (MNDs) are a debilitating subset of diseases, which result in
progressive neuronal destruction and eventual loss of voluntary muscular function. These …

Amyotrophic lateral sclerosis: cell vulnerability or system vulnerability?

K Talbot - Journal of anatomy, 2014 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with clinical,
pathological and genetic overlap with frontotemporal dementia (FTD). No longer viewed as …

Amyotrophic lateral sclerosis: an update

M de Carvalho, M Swash - Current opinion in neurology, 2011 - journals.lww.com
ALS research is entering a new phase that should generate new proposals regarding
putative therapies, or strategies for disease treatment. A continuing difficulty, however, is …

[HTML][HTML] Clusters of anatomical disease-burden patterns in ALS: a data-driven approach confirms radiological subtypes

P Bede, A Murad, J Lope, O Hardiman, KM Chang - Journal of neurology, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity
spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent …

[HTML][HTML] Motor network degeneration in amyotrophic lateral sclerosis: a structural and functional connectivity study

E Verstraete, MP Van Den Heuvel, JH Veldink… - PloS one, 2010 - journals.plos.org
Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
characterised by motor neuron degeneration. How this disease affects the central motor …