Neurotransmitters play critical roles in the developing nervous system. Among the
neurotransmitters, norepinephrine (NE) is in particular postulated to be an important …

Activity regulated cytoskeletal protein (Arc), c-fos and zif268 are immediate early genes
(IEGs) important for adult brain plasticity. We examined developmental expression of these …

The norepinephrine transporter (NET) plays a major role in regulating the actions of
norepinephrine by removing norepinephrine from the synapse. Many studies suggest …

Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central
nervous system (CNS) norepinephrine are being developed targeting noradrenergic …

Hypothalamic noradrenergic utilization in vivo and the in vitro depolarized release of
norepinephrine (NE) were measured at 28, 42, and 70 days of age in male rats to determine …

Publisher Summary This chapter describes neurotransmitters as developmental signals in
key ontogenic processes, such as neural tube formation, germinal cell proliferation, and …

Thenorepinephrine transporter (NET) is a neurotransmitter scavenger and site of drug action
in noradrenergic neurons. The aim of this study was to identify mechanisms that regulate …

Background We have identified a differential gene expression profile in neural crest stem
cells that is due to deletion of the norepinephrine transporter (NET) gene. NET is the target …

In order to evaluate mechanisms that could contribute to the effect of adolescent
development on the in vivo utilization of norepinephrine (NE) in the hypothalamus, the …

Publisher Summary The purpose of this chapter is to provide foundations for a working
hypothesis on drug-induced functional neuroteratology. A class of centrally acting …