Analysis of opioid-seeking behavior through the intravenous self-administration reinstatement model in rats
The inability to maintain drug abstinence is often referred to as relapse and consists of a
process by which an abstaining individual slips back into old behavioral patterns and …
process by which an abstaining individual slips back into old behavioral patterns and …
Role of opioid receptors in the reinstatement of opioid-seeking behavior: an overview
Opioid abuse in humans is characterized by discontinuous periods of drug use and
abstinence. With time, the probability of falling into renewed drug consumption becomes …
abstinence. With time, the probability of falling into renewed drug consumption becomes …
Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawal
It is widely believed that opioid withdrawal symptoms contribute to relapse to opioid use, but
relapse is highly probable in experienced users even after prolonged abstinence and during …
relapse is highly probable in experienced users even after prolonged abstinence and during …
Mechanisms of withdrawal-associated increases in heroin self-administration: pharmacologic modulation of heroin vs food choice in heroin-dependent rhesus …
SS Negus, KC Rice - Neuropsychopharmacology, 2009 - nature.com
Opioid withdrawal can produce a constellation of physiological and behavioral signs,
including an increase in opioid self-administration. Different mechanisms mediate different …
including an increase in opioid self-administration. Different mechanisms mediate different …
Relapse to opioid seeking in rat models: behavior, pharmacology and circuits
DJ Reiner, I Fredriksson, OM Lofaro… - …, 2019 - nature.com
Lifetime relapse rates remain a major obstacle in addressing the current opioid crisis.
Relapse to opioid use can be modeled in rodent studies where drug self-administration is …
Relapse to opioid use can be modeled in rodent studies where drug self-administration is …
Animal models of relapse.
ME Carroll, SD Comer - Experimental and Clinical …, 1996 - psycnet.apa.org
This review focuses upon an animal model of relapse. The basic model is to establish that a
drug is functioning as a reinforcer. Drug is then replaced with vehicle, and responding is …
drug is functioning as a reinforcer. Drug is then replaced with vehicle, and responding is …
Reinstatement of punishment-suppressed opioid self-administration in rats: an alternative model of relapse to drug abuse
LV Panlilio, EB Thorndike, CW Schindler - Psychopharmacology, 2003 - Springer
Rationale. Animal models of relapse to drug abuse typically assess the ability of various
manipulations to reinstate responding that has ceased due to non-reinforcement (extinction) …
manipulations to reinstate responding that has ceased due to non-reinforcement (extinction) …
How will we know a lapse when we see one?: Comment on Leri and Stewart (2002).
TB Baker, JJ Curtin - 2002 - psycnet.apa.org
The article by F. Leri and J. Stewart (see record 2002-06535-001) addresses the validity of
animal models of relapse in a more sophisticated manner than does much prior research …
animal models of relapse in a more sophisticated manner than does much prior research …
The reinstatement model of drug relapse: history, methodology and major findings
Rational and objectives. The reinstatement model is currently used in many laboratories to
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …