Macrophages are key contributors to vascularization, but the mechanisms behind their
actions are not understood. Here, we show that diverse macrophage phenotypes have …

Angiogenesis is crucial for the success of most tissue engineering strategies. The natural
inflammatory response is a major regulator of vascularization, through the activity of different …

Tissue engineering is increasingly based on recapitulating human physiology, through
integration of biological principles into engineering designs. In spite of all progress in …

Notwithstanding the remarkable progress in vascular network engineering, implanted
bioengineered microvessels mostly fail to form anastomoses with the host vasculature. Here …

Monocytes are circulating leukocytes of innate immunity derived from the bone marrow that
interact with endothelial cells under physiological or pathophysiological conditions to …

Tissue engineering holds great promise in regenerative medicine. However, the field of
tissue engineering faces a myriad of difficulties. A major challenge is the necessity to …

BACKGROUND Vascular replacement and repair for the treatment of atherosclerotic
disease, infection, and traumatic injury are some of the most commonly performed surgical …

Although vascular bypass grafting remains the mainstay for revascularization for ischemic
heart disease and peripheral vascular disease, many patients do not have healthy vessels …

Blood vessels transport blood to deliver oxygen and nutrients. Vascular diseases such as
atherosclerosis may result in obstruction of blood vessels and tissue ischemia. These …

Blood vessel networks expand in a 2-step process that begins with vessel sprouting and is
followed by vessel anastomosis. Vessel sprouting is induced by chemotactic gradients of the …