INTRODUCTION—The production of myeloid cells (granulocytes and monocytes) is a tightly
regulated process. During steady-state hematopoiesis, approximately 10 8 to 10 9 of these …

The formed elements of blood include various types of cells or cell fragments, each with
different morphology and function. These elements are produced via a process known as …

Innate myeloid immune cells, and neutrophils in particular, serve as first line of defense
against pathogenic microorganisms including bacteria and fungi. Given their short life span …

Myelopoiesis ensures the steady state of the myeloid cell compartment. Technological
advances in fate mapping and genetic engineering, as well as the advent of single cell RNA …

In an effort to gain insight into human pathophysiology, blood is one of the most frequently
sampled biological products. Generation of the cellular elements of blood is the end result of …

Neutrophils are the most abundant circulating leukocyte and play a fundamental role in the
innate immune response. Patients with neutropenia, leukocyte adhesion deficiency …

Neutrophil granulocytes represent the first immunologic barrier against invading pathogens,
and neutropenia predisposes to infection. However, neutrophils may also cause significant …

4A 14 days; cell division is terminated at the metamyelocyte stage, while granule
development continues. Eventually, terminally differentiated neutrophils are released from …

The bone marrow is responsible for the generation of cells of the blood and many of the
principal components of the immune system. Early in embryonic life a small population of …

Highlights•Myeloid-cell regulation optimizes innate/adaptive immunity and tissue
health.•Competing positive and negative signaling biases and tunes myeloid activation.•Src …