[HTML][HTML] E-cigarette fluids and aerosol residues cause oxidative stress and an inflammatory response in human keratinocytes and 3D skin models

C Khachatoorian, W Luo, KJ McWhirter, JF Pankow… - Toxicology in Vitro, 2021 - Elsevier
Our goal was to evaluate the effects of EC refill fluids and EC exhaled aerosol residue
(ECEAR) on cultured human keratinocytes and MatTek EpiDerm™, a 3D air liquid interface …

Inflammatory and oxidative responses induced by exposure to commonly used e-cigarette flavoring chemicals and flavored e-liquids without nicotine

T Muthumalage, M Prinz, KO Ansah, J Gerloff… - Frontiers in …, 2018 - frontiersin.org
Background: The respiratory health effects of inhalation exposure to e-cigarette flavoring
chemicals are not well understood. We focused our study on the immuno-toxicological and …

Characterization of electronic cigarette aerosol and its induction of oxidative stress response in oral keratinocytes

EH Ji, B Sun, T Zhao, S Shu, CH Chang, D Messadi… - PloS one, 2016 - journals.plos.org
In this study, we have generated and characterized Electronic Cigarette (EC) aerosols using
a combination of advanced technologies. In the gas phase, the particle number …

Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse …

CA Lerner, IK Sundar, H Yao, J Gerloff, DJ Ossip… - PloS one, 2015 - journals.plos.org
Oxidative stress and inflammatory response are the key events in the pathogenesis of
chronic airway diseases. The consumption of electronic cigarettes (e-cigs) with a variety of e …

[HTML][HTML] Pro-inflammatory effects of aerosols from e-cigarette-derived flavoring chemicals on murine macrophages

T Lamb, I Rahman - Toxicology Reports, 2023 - Elsevier
Macrophages treated with the flavoring chemicals found in flavored electronic cigarettes
have been shown to induce an inflammatory response, however, limited data are available …

[HTML][HTML] Toxicological comparison of cigarette smoke and e-cigarette aerosol using a 3D in vitro human respiratory model

L Czekala, L Simms, M Stevenson, N Tschierske… - Regulatory Toxicology …, 2019 - Elsevier
With the growing prevalence of e-cigarettes as an alternative to conventional cigarettes
amongst smokers worldwide, there is a need for new methods to evaluate their relative …

Effects of e-cigarette flavoring chemicals on human macrophages and bronchial epithelial cells

AM Morris, SS Leonard, JR Fowles, TE Boots… - International Journal of …, 2021 - mdpi.com
E-cigarettes utilize a wide range of flavoring chemicals with respiratory health effects that are
not well understood. In this study, we used pulmonary-associated cell lines to assess the in …

[HTML][HTML] Increased oxidative stress responses in murine macrophages exposed at the air-liquid interface to third-and fourth-generation electronic nicotine delivery …

R Pinkston, AL Penn, A Noël - Toxicology Reports, 2023 - Elsevier
Background New fourth generation electronic nicotine delivery system (ENDS) devices
contain high levels of nicotine salt (up to 60 mg/mL), whose cellular and molecular effects on …

Inflammatory response and barrier dysfunction by different e-cigarette flavoring chemicals identified by gas chromatography–mass spectrometry in e-liquids and e …

J Gerloff, IK Sundar, R Freter, ER Sekera… - Applied in vitro …, 2017 - liebertpub.com
Recent studies suggest that electronic cigarette (e-cig) flavors can be harmful to lung tissue
by imposing oxidative stress and inflammatory responses. The potential inflammatory …

A novel clinical method to measure skin staining reveals activation of skin damage pathways by cigarette smoke

A Dalrymple, M McEwan, M Brandt… - Skin Research and …, 2022 - Wiley Online Library
Background Long‐term use of cigarettes can result in localised staining and aging of
smokers' skin. The use of tobacco heating products (THPs) and electronic cigarettes (ECs) …