Effects of alpha-fetoprotein on the occurrence and progression of hepatocellular carcinoma

Y Zheng, M Zhu, M Li - Journal of cancer research and clinical oncology, 2020 - Springer
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world.
Alpha-fetoprotein (AFP) is considered as a diagnostic and prognostic tumorous marker for …

[HTML][HTML] Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma

P Li, SS Wang, H Liu, N Li, MA McNutt… - World Journal of …, 2011 - ncbi.nlm.nih.gov
AIM: To investigate the biological role of alpha fetoprotein (AFP) and its clinical significance
in carcinogenesis of hepatocellular carcinoma (HCC). METHODS: Clinical analysis of HCC …

Biology and significance of alpha‐fetoprotein in hepatocellular carcinoma

PR Galle, F Foerster, M Kudo, SL Chan… - Liver …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer‐related
deaths globally due, in part, to the majority of patients being diagnosed with intermediate or …

Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells

Y Lu, M Zhu, W Li, B Lin, X Dong… - Journal of Cellular …, 2016 - Wiley Online Library
A high level of serum alpha fetoprotein (AFP) is positively associated with human
hepatocellular carcinoma (HCC) carcinogenesis and metastasis; however, the function of …

High α‐fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 …

SY Peng, WJ Chen, PL Lai, YM Jeng… - … journal of cancer, 2004 - Wiley Online Library
Abstract α‐Fetoprotein (AFP) is often elevated in hepatocellular carcinoma (HCC). This
study was to elucidate the significance and related factors of AFP elevation in HCC in 781 …

[HTML][HTML] AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway

T Chen, X Dai, J Dai, C Ding, Z Zhang, Z Lin, J Hu… - Cell death & …, 2020 - nature.com
Hepatocellular carcinoma (HCC) is a major leading cause of cancer-related death
worldwide. Alpha fetoprotein (AFP) is reactivated in a majority of hepatocellular carcinoma …

Comprehensive clinicopathologic study of alpha fetoprotein‐expression in a large cohort of patients with hepatocellular carcinoma

DA Ridder, A Weinmann… - … journal of cancer, 2022 - Wiley Online Library
Alpha fetoprotein (AFP) is the most widely used diagnostic and prognostic serum biomarker
for hepatocellular carcinoma (HCC). Despite its wide clinical use, a systematic …

[HTML][HTML] The landscape of alpha fetoprotein in hepatocellular carcinoma: where are we?

X Hu, R Chen, Q Wei, X Xu - International Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has been
acknowledged as a leading cause of death among cirrhosis patients. Difficulties in early …

Determinants of alpha‐fetoprotein levels in patients with hepatocellular carcinoma: implications for its clinical use

EG Giannini, G Sammito, F Farinati, F Ciccarese… - Cancer, 2014 - Wiley Online Library
BACKGROUND α‐Fetoprotein (AFP) is a biomarker commonly used in the management of
patients with hepatocellular carcinoma (HCC), although the possible determinants of its …

α-Fetoprotein impairs APC function and induces their apoptosis

SH Um, C Mulhall, A Alisa, AR Ives… - The Journal of …, 2004 - journals.aai.org
Abstract α-Fetoprotein (AFP) is a tumor-associated Ag, and its serum level is elevated in
patients with hepatocellular carcinoma (HCC). In vitro, AFP induces functional impairment of …